This article is concerned with the history and current state of research activities into medical expert systems (MES) in Japan. A brief review of expert systems' work over the last ten years is provided and here is a discussion on future directions of artificial intelligence (AI) applications in medicine, which we expect the Japanese AI community in medicine (AIM) to undertake.

Specificities of enzymes involved in plant specialized metabolism, including flavonoid biosynthesis, are generally promiscuous. This enzyme promiscuity has served as an evolutionary basis for new enzyme functions and metabolic pathways in land plants adapting to environmental challenges. This phenomenon may lead, however, to inefficiency in specialized metabolism and adversely affect metabolite‐mediated plant survival. How plants manage enzyme promiscuity for efficient specialized metabolism is, thus, an open question. Recent studies of flavonoid biosynthesis addressing this issue have revealed a conserved strategy, namely, (...) a homolog of chalcone isomerase with no catalytic activity binds to chalcone synthase, a key flavonoid pathway enzyme, to narrow (or rectify) the enzyme's highly promiscuous product specificity. Reducing promiscuity via specific protein–protein interactions among metabolic enzymes and proteins may be a solution adopted by land plants to achieve efficient operation of specialized metabolism, while the intrinsic promiscuity of enzymes has likely been retained incidentally. (shrink)

戦乱の世に仁義道徳を主張して学団を組織し、志士仁人の道を説いた中国古代の思想家・孔子と、民国初期の植民地化という危機を背景に、国民性の改革をめざした魯迅。中国史の豊かな素養を背景に、彼らの活動に共通す る「教育」という側面に着目し、国家と社会の「教育」に生涯を掛けたその思想と行動を浮き彫りにする。.

The present paper studies self-awareness and introduces some self-awareness related incidents. It then describes the relationship between self-awareness and consciousness and explains the MoNAD, a neural network circuit developed by the authors that capably describes the phenomena of self-awareness and consciousness. A model of self-awareness is then presented. This self-awareness model is a parallel network system in which multiple independent MoNADs communicate with one another. In experiments with robots, three test robots were used: (1) a self-image robot reflected in a (...) mirror, (2) another robot, and (3) a cable-connected robot behaving as commanded by the self-robot. The reactions of the three test robots to the self-robot were compared to investigate the self-awareness of the self-robot. The experiments have shown that the conditions required for the self-robot to interpret the test robot to be part of itself are: (1) the test robot must return a reaction within a certain period of time that is inte.. (shrink)

This article deals with the semantics of “double-access” sentences. They are defined as English sentences which have a past tense morpheme in the matrix clause and a present tense morpheme in a subordinate clause in the immediate scope of the matrix past tense. They receive a very peculiar interpretation, which we will refer to as a “double-access interpretation.” The episode described in the embedded clause makes reference to two times: the time referred to by the matrix predicate and the utterance (...) time of the whole sentence. Previous studies on this construction are largely descriptive and do not attempt to analyze it formally, with one important exception. Abusch (1991) addresses the problems connected with the construction and proposes that double-access interpretations involvede re attitudes about intervals. Her proposal contains an important insight and provides one possible account of the double-access construction. My proposal was independently developed at approximately the same time as Abusch's and offers an alternative explanation for the phenomena. I consider a series of hypotheses and conclude that double-access readings involvede re attitude reports about state individuals. This account is couched in an eventuality-based framework and employs the techniques proposed by Cresswell and von Stechow (1982). In order to yield the desired reading, the tense must first adjoin to the complement S, then to the matrix S, leaving two traces in the process. (shrink)

This article discusses what may be referred to as ``adjectival relatives''''in Japanese and related constructions in other languages (such asadjectival passives in English). The most intriguing characteristicof this construction is that the verb contained in it occurs in the pasttense form, but its primary role is to describe a state that obtains atthe local evaluation time, rather than the past event that producedthis state. In fact, in some cases, the putative event that presumablyproduced the target state is non-existent, and the (...) entire constructionreceives a purely stative interpretation. In other words, it is possiblefor an adjectival relative to describe a target state without having itstriggering event. The proposal I put forth in the article states that whatI refer to as an adjectival relative does not have a clausal structure.It rather has a verbal projection (technically a Tense Phrase, or TP). Mod(the modifier head) then combined with TP to yield a MP (modifierphrase), which denotes a property of states that appear to have resultedfrom an event the verb describes. In order to reach this conclusion, I adopttwo additional ideas: (i) Kratzer''s (1996) idea that the so-called externalargument of a verb is not really its argument at all; (ii) direct causationdoes not have to be overtly represented in natural language syntax (Bittner1999). Having incorporated these two ideas, the proposal explains therelation between the state that the adjectival relative describes and theputative event as a modal one, thereby accounting for the non-existenceof putative past events in some examples. (shrink)

The external worlds do not objectively exist for living systems because these worlds are unknown from within systems. How can they escape solipsism to survive and reproduce as open systems? Living systems must construct their hypothetical models of external entities in the form of their internal structures to determine how to change states (i.e., sense and act) appropriately to achieve a favorable probability distribution of the events they experience. The model construction involves the generation of symbols referring to external entities. (...) This paper attempts to provide a new view that living systems are an inverse-causality operator. Inverse causality (IC) is an algorithmic process that generates symbols referring to external reality states based on a given data sequence. For applying this logical model involving if–then entailments to living systems involving material interactions, the cognizers-system model was employed to represent the IC process; here, living systems were modeled as a subject of cognition and action. A focal subject system is described as a cognizer composed of sub-cognizers, such as a sensor, a signal transducer, and an effector. Analysis using this model proposes that living systems invented the “measurers” for conducting IC operations through their evolution. (shrink)

Researchers are able to estimate what subjects attend to by using eye tracking systems. Existing approaches for analyzing eye movements are very useful to estimate attention to still objects. But they are inadequate to estimate attention to moving objects, although paying attention to moving objects is usual human behavior. Thus, we propose a novel approach and algorithm to estimate attention to moving objects more precisely. Our approach is to extract "eye tracking movements". We phrase both saccadic eye movements and smooth (...) pursuit eye movements as "eye tracking movements". Because previous works reveal that humans often track a moving object by the eye movements when they pay attention to the object, our approach seems to be appropriate. Our algorithm used for extracting eye tracking movements is called Path Stitching (PS) algorithm. The PS algorithm is a kind of Longest Common Subsequence (LCS) discovery algorithms using Dynamic Time Warping (DTW) as a similarity measurement procedure. Eye tracking movements can be regarded as a situation that a subsequence of eye movements' trajectory is similar to a subsequence of the target's trajectory with a small or no time-difference. Because humans track a moving object by the eye movements with locally fluctuated time difference, we think the use of DTW is very appropriate. In addition, to make outputs more comprehensible, we employ the LCS discovery approach for the PS algorithm. The experimental results show that the PS algorithm is more able to extract eye tracking movements than the fixation extracting approach. The fixation extracting approach is the most popular and the strongest approach to analyze eye movements. Therefore, we conclude that our novel approach will advance the analysis of human behavior by the eye movements and human-computer interaction systems they utilize user's eye movements. (shrink)

It is often assumed that the reaction time of a saccade toward visual and/or auditory stimuli reflects the sensitivities of our oculomotor-orienting system to stimulus saliency. Endogenous factors, as well as stimulus-related factors, would also affect the saccadic reaction time. However, it was not clear how these factors interact and to what extent visual and auditory-targeting saccades are accounted for by common mechanisms. The present study examined the effect of, and the interaction between, stimulus saliency and audiovisual spatial congruency on (...) the SRT for visual- and for auditory-target conditions. We also analyzed pre-target pupil size to examine the relationship between saccade preparation and pupil size. Pupil size is considered to reflect arousal states coupling with locus-coeruleus activity during a cognitive task. The main findings were that the pattern of the examined effects on the SRT varied between visual- and auditory-auditory target conditions, the effect of stimulus saliency was significant for the visual-target condition, but not significant for the auditory-target condition, Pupil velocity, not absolute pupil size, was sensitive to task set, and there was a significant correlation between the pre-saccade absolute pupil size and the SRTs for the visual-target condition but not for the auditory-target condition. The discrepancy between target modalities for the effect of pupil velocity and between the absolute pupil size and pupil velocity for the correlation with SRT may imply that the pupil effect for the visual-target condition was caused by a modality-specific link between pupil size modulation and the SC rather than by the LC-NE system. These results support the idea that different threshold mechanisms in the SC may be involved in the initiation of saccades toward visual and auditory targets. (shrink)

Analytic study of the Advaita philosophy of Śaṅkarācārya and its schools.

This paper extends studies on intertextuality into a more explicitly interactional context. I examine the actual process of intertextuality where comedy audiences construct recombinant selves through making sense of various membership categories as well as through making sense of a certain kind of comedy. The examination of this process requires receptive research; however, most studies leave the interpretive process unanalyzed. Conducting both a sequential analysis and a membership categorization analysis will reveal that categories are not “pre-formed” but “per-formed” in situ. (...) To illustrate these points, I report on a receptive study of Local comedy in Hawai‘i. (shrink)

This article reviews recent findings that bear on the mechanism(s) of tumor‐specific Lyt‐1+2− T cell‐mediated tumor eradication in vivo A tumor‐immune Lyt‐1+2− T cell subset has been identified which is distinct from T cells mediating in vitro cytotoxicity (Lyt‐1+2+/1−2+). The Lyt‐1+2− cells have a crucial role in rejecting tumor cells when adoptively transferred into T cell‐deprived B cell mice. This indicates that Lyt‐1+2− T cells do not necessarily require recruitment of the host's cytotoxic T cell precursors for implementation of in (...) vivo immunity. Instead, this T cell subset exerts its anti‐tumor effect in collaboration with macrophages as shown with an in vivo tumor cell culture system utilizing a diffusion chamber. A pathway of Lyt‐1+2− T cell‐macrophage interaction leading to tumor cell killing is discussed in terms of its probable relevance to the eradication of tumor cell masses consisting of tumor cells expressing quantitatively and/or qualitatively different tumor antigens. (shrink)

A partir de algunos motivos presentes en Poesie in forma di rosa, La Divina Mimesis y, sobre todo, Petrolio, atenderemos algunos motivos de la propuesta estética de Pasolini en relación con la crítica de lo político. Lo que inicialmente parece una crítica o semiología de la sociedad y lo político se revela, con el tiempo, como un problema artístico en el cual el arte es en sí político y lo político es en sí artístico. Este asunto no es más que (...) el de la forma tal y como aparece en las mencionadas obras del poeta. (shrink)

A relatively high incidence of unsatisfactory review decisions is widely recognised and acknowledged as ‘the peer review problem’. Factors contributing to this problem are identified and examined. Specific examples of unreasonable rejection are considered. It is concluded that weaknesses of the ‘peer review’ system are significant and that they are well known or readily recognisable but that necessary counter-measures are not always enforced. Careful management is necessary to discount hollow opinion or error in review comment. Review and referee functions should (...) be quite separate. (shrink)

偶然を「運命」として生きる生き方とは何か。九鬼周造が哲学的思索の果てにたどりついた世界観を明らかにする。.

大学、学会、企業、国家などと関わりながら「制度化」の歩みを進めて来た西洋科学。現代に至るまでの歴史を概観した入門書。.